LuckCong's Health Blog

TTV virus could become the eighth, hepatitis virus. No. 81 Hospital of the PLA Nanjing Military Institute of liver disease in patients with liver disease in Nanjing in testing a TTV of the virus, known as the Nanjing TTV strains of the virus, and many had concluded that, TTV is a virus Anopheles species of liver virus, with pathogenicity. Prior to the international community has found there are 7 kinds of hepatitis virus, have been numbered to a hepatitis G virus. December 1997 also reported that foreign a new type of hepatitis virus, which has often transmitted through blood transfusion. It is known as transfusion-transmitted virus (transfusion transmitted Virus), that is, TTV virus. In May 1998, the Institute of the Nanjing Military Region, liver disease, such as Professor Xu Jiazhang the start of TTV virus research. On their non-A to G hepatitis patients with non-detected virus TTV, cloning and gene sequencing analysis of the Ming Zhiwei TTV strains of the virus in Nanjing, China. Study, they have set up TTV virus in vitro nucleic acid amplification technology, for a total of 390 cases of hepatitis patients had tested positive for the virus were detected TTV were 48 cases in which a single TTV infection in 18 cases. In that 18 cases of single TTV HIV, people living with chronic 1; 10 cases of chronic hepatitis; chronic hepatitis (heavy) 1; 1 case of acute hepatitis; 3 cases of liver cirrhosis; 2 cases of severe hepatitis. These patients have a persistent increase in transaminase, liver damage, and other clinical symptoms, which have 1 case of ascites, severe hepatitis and 2 cases were combined liver and kidney syndrome death. Study, the researchers of 7 cases of which have done a liver biopsy and found that there are various types of liver cell necrosis, such as what necrotic debris, the point of necrosis, focal necrosis, and so on, the District Department of the liver have a large number of lymphocytes, inflammatory cells Infiltration, which confirmed the virus TTV pathogenic. Professor Xu Jiazhang of the view that China is a high incidence liver disease, TTV virus in the population of the higher detection rate, now an urgent need for this was also new to the hepatitis virus in-depth research, such as research organizations, prospective study to establish HIV infections TTV animal model to better guide clinical treatment. (Feng), TTV infection lamivudine therapy effective In the 50th National Institute of Liver Disease annual meeting, Spain Barcena, and other reports of lamivudine TTV (transfusion transmited virus) infection have a certain effect. TTV in Japan and Africa to a post-transfusion hepatitis E patients found that a new viral DNA. It seems to be unexplained liver and fulminant hepatic failure related to the incidence. According to the report, in which chronic hepatitis C patients with chronic hepatitis B and a higher rate of incidence. Barcena, such as the study of lamivudine TTV infection. Research into a total of 23 cases of chronic active hepatitis B patients, 15 cases of TTV positive. All patients received lamivudine 100mg / d, treatment for at least 5 years. In the pre-treatment, the treatment is started a month, two to three months, at least every 3 months at a blood serum samples stored in -70 ℃. Each patient testing at least 3 times: before treatment, the treatment is started 2 to 6 months before the detection and TTV. Using high-grade virus nucleic acid extraction kit DNA, and then semi-nested PCR detection of TTV. Liver transplant patients in the transplant after 2 to 4 months of blood. The results showed that 15 cases of TTV-positive patients, 10 patients underwent liver transplantation, 5 patients did not receive liver transplantation (4 cases which had lost blood). TTV and HCV co-infection 5. The median age for patients (50.0 ± 8.8) years old, 10 cases of men. During the treatment, 14 patients in 12 cases of TTV DNA negative, with 10 cases last 1 serum samples are still negative, and the other 2 cases (16%) patients after positive. 2 cases of patients during the treatment of TTV DNA has been positive. Effective and ineffective in the course of treatment, HCV infection and liver transplant patients in such areas as there was no significant difference. Researchers believe that the TTV infection treated with lamivudine better efficacy, 88.1% of patients during the treatment of TTV negative. However, 16% of patients in the course of treatment positive, suggesting that in the long-term treatment, a considerable portion of the virus may lamivudine resistance.