LuckCong's Health Blog

End of the year, a lot of entertainment. For patients with hepatitis B, the frequent disruption of the original laws of the dinner will be the diet, is easy for the virus to control instability. Medical experts stressed infection, hepatitis B patients during the festive season, we have to retain a normal diet and rest habits, to avoid overeating and fatigue, will be very easy to cause illness repeatedly. Avoid drinking less greasy conventional diet In winter, large temperature difference between morning and evening, the weather changes, especially in patients with hepatitis B need to focus on treatment and maintenance. But in fact, many patients will relax in the festive "disease management." National Network of liver disease liver disease experts remind liver friends, at the end of festivals, and entertainment inevitable, but some patients with hepatitis is possible that a number of festivals liver taboo committed an error, such as drinking, eating too much greasy food , tiredness and so on, the virus triggered a rebound, his condition repeatedly. "Hepatitis patients or carriers of hepatitis C virus is an absolute need to refrain from drinking because alcohol metabolism through the liver will produce a large number of free radicals are toxic metabolites liver, adding to the burden of the liver. So, that wine is the liver's' poison 'is not too much . " For patients with liver disease, the proposed best digestible food for human consumption, such as rice, pasta, vegetables, fruits, meat amount, high-fat foods to eat less greasy. Excessive consumption of hot food such as lamb, dog and too spicy food on the liver particularly detrimental. Festivals have to regularly review the medication on time Frequent dinner gatherings and friends will not only disrupt the law of hepatitis life, but also easy for patients to forget a regular basis for treatment or referral, it is easy for the virus to control instability, efficacy greatly reduced. Experts believe that the treatment of patients for follow-up referral is very important to see a doctor regularly to understand the severity of their illnesses, such as monitoring the virus, changes in liver function can also be indicators of drug efficacy and side effects. Half-way stop will affect the efficacy and even give rise to serious liver disease aggravated consequences. The medication does not referral, it is possible side effects or miss on the early detection of drug resistance, resulting in great danger. Cold may cause hepatitis B recurrence "Chronic hepatitis B patients in the seasonal variation, because of susceptibility to colds and other respiratory diseases, is likely to cause recurrence of hepatitis." On the seasonal changes, liver disease to comply with health and good health in general, such as attention to rest; the prevention of influenza; Maintain calm and so comfortable. Here in particular, would like to remind, hepatitis B patients, especially over exertion can not stay up all night, because people stay up all night, it will cause the decline in immunity, this will lead to increased viral replication of hepatitis B, liver burden.

To understand whether the spread of hepatitis B kissing, we must first understand the mode of transmission of hepatitis B virus, the latest release of "Chronic hepatitis B prevention and treatment guidelines" explicitly pointed out: Hepatitis B virus (HBV) the main blood and blood products, maternal and child, broken skin and mucous membrane, and sexual contact. Perinatal (production) period of mother to child transmission of hepatitis B transmission is the main mode, multi-contact in the delivery of hepatitis B virus-positive mother's blood and body fluids. By mucocutaneous dissemination occurred mainly in the use without a strict disinfection of medical equipment, syringes, invasive operation and surgical clinics, as well as intravenous drug abuse. Other factors, such as repair feet, tattoos, earrings hole bar, medical personnel in the work of accidental exposure, sharing of razors and toothbrushes, such as hepatitis B can also be disseminated. Sexual contact with hepatitis B patients, especially in multiple sexual partners, their risk of hepatitis B infection was significantly increased. Blood donors because of the strict implementation of hepatitis B surface antigen screening, by the transfusion of contaminated blood or blood products caused by hepatitis B infection have been less frequent. Working or living day-to-day contacts, as an office work (including the share of computers and other office supplies), shaking hands, hugging, sharing a dormitory, dining and sharing the same toilet without blood exposure, such as contacts, transmission of hepatitis B is generally not. It is totally not necessary to talk about hepatitis B terribly. By blood-sucking insects (mosquitoes, bugs, etc.) the possibility of the spread of hepatitis B has not been proven. To prevent hepatitis B infection in the most simple and effective method is injection of hepatitis B vaccine, hepatitis B patients and should be taken to avoid contact with skin and mucous membrane damage. Because of hepatitis B patients can be found in saliva complete hepatitis B virus, so when and lovers kissing mucocutaneous damage caused as a result of the dissemination of the possibility of hepatitis B or some, but because of hepatitis B virus content is extremely low, so infected with hepatitis B also a very small chance of a very small. The best way to prevent hepatitis B is still yet to hepatitis B virus infection in the whole of the normal injection of hepatitis B vaccine to produce protective antibodies.

As we all know, a very high nutritional value of milk, fresh milk rich in protein and calcium, magnesium and vitamin B1, B2, C. Hepatitis B patients the benefits of a lot of milk. Patients with liver disease should drink 2 cups of milk a day, it can add to the daily requirements of protein, 1 / 10, the daily requirements of vitamin B2 1 / 4 and vitamin A, 1 / 8. However, the milk also need the right way, otherwise will play a counter-productive. Hepatitis B patients to drink milk should be noted: 1. Elderly patients with hepatitis B it is inadvisable: As of lactose in milk under Lactase decomposed into galactose, excessive galactose can be deposited on the eye lens, the trigger cataract. 2. Hepatitis B acute or chronic hepatitis B activity period, nausea, vomiting, abdominal distension were fed up with oil and should not be drinking milk. In the digestive tract symptoms and rehabilitation period of drinking for good. Liver cirrhosis with hepatic coma or hepatic coma tendencies should not drink milk, otherwise they will be in a coma induced liver. 3. Should not be an empty stomach to drink: If an empty stomach to drink milk, milk protein can only replace the carbohydrate calories to be transformed into consumption, the new organization would not serve any purpose of protein structure, repair the old organizations. 4. Not a large or big mouth to drink: milk contains 5% lactose, lactase when the body is low, too fast to drink too much milk, lactose digestion and absorption can not easily cause bloating, diarrhea. Therefore, timely milk drink small mouth, saliva and milk to be ingested after mixing. 5. Should not be drinking sugar: sucrose in the gastrointestinal tract because the decomposition products will work with the calcium in milk and, not only is not conducive to the absorption of calcium, it will promote bacterial fermentation gas production, resulting in abdominal distension.

The maintenance of human daily life required for normal physiological metabolism of protein, about 70g per day, while hepatitis B patients with liver repaired, put the demand for larger, daily should be maintained at around 100g. Protein-rich food are mainly fish, eggs, milk and meat of animals, as well as various soy products, protein in the process, the Government should do with animal and plant protein, balanced, thus ensuring that different amino acids Perturbation income. Although protein is very important, but not better, if supply exceeded demand for a day, will increase the burden on the liver, increasing fat synthesis, severe cases led to fatty liver. Patients with severe liver disease, such as hepatitis, advanced cirrhosis and hepatic coma tendency should be replaced by low-protein diet. Because the protein is a kind of ammonia material, the process of metabolism in the body can produce ammonia, and ammonia is toxic to humans. When severely damaged liver function, the role of the liver Deaminase receded, increased blood ammonia to produce one of the main causes of hepatic coma. Commonly used in food protein content (%) The name of the protein content of food protein content of food names 13.3 ~ 18.5 flour pork 11.0 Beef 15.8 ~ 21.7 Soybean 39.2 14.3 ~ 18.7 peanut lamb 25.8 21.5 chicken turnip 0.6 Lei 18.1 cabbage 1.1 13.4 spinach egg 1.8 Milk 3.3 Rape 1.4 Rice 8.5 cucumber 0.8 Wheat 12.4 Orange 0.9 Millet 9.7 Apple 0.2 Corn 8.6 sweet potato 1.3 Sorghum 9.5 An average of 100 grams of protein nitrogen content of 16 grams per gram of nitrogen that is the equivalent of 6.25 grams of protein (100/16 = 6.25). So as long as the determination of biological samples in the nitrogen content, which can calculate the approximate protein content. Per gram sample containing a few grams of sample χ6.25χ100 = 100 grams of protein content (grams%). The basic unit of protein is the amino acid.

There are a lot of clinical hepatitis B liver function in patients with long-term stability, all of a sudden, the body was feeling unwell, the situation of hepatitis B recurrence. These are what cause? Caused by hepatitis B recurrence reasons: 1. Diet: hepatitis patients when eating light, nutritious food mainly to avoid eating greasy, fried, spicy food, it is difficult to digest these foods, will add to the burden of gastrointestinal,of goods, easy to pent-up emotion stomach into a hot and humid, damage the spleen and stomach, induces hepatitis attack. Recurrence of hepatitis caused by alcohol is one of the major wine in Intrahepatic oxidation, the formation of harmful substances Acetaldehyde can directly damage the liver, hepatitis must therefore temperance. 2. Overworked: over exertion (including heavy manual and mental), can undermine the relative balance the body's immune status, to hepatitis B virus replication intensified, increasing the burden on the liver, resulting in the recurrence of hepatitis. Overworked situation are as follows: long distances, stay up all night, the spirit of high tension, work pressure, mood swings, rage and sexual assault as well as the frequency and so too. 3. Seasonal variation: Hepatitis attack different season, spring and summer season for hepatitis easy to attack, autumn and winter fat Author relatively small, seasonal fluctuations in the probability of liver function are: fluctuations in the spring, about 22.94% in summer accounted for 23.85 percent, accounting for 9.17% in autumn and winter accounted for 18.34 percent. 4. To change the environment: The patient in stable condition shortly after a change in the original lifestyle and living environment, such as business, travel and so on, because the living environment, water and soil conditions change, resulting in disorder in the body appear abnormal liver function. 5. Wrongly or abuse of drugs: hepatitis patients to seek eager, often believe the advertising, taking a variety of home-made traditional Chinese medicine preparation; some long-term use "remedy", "prescription", and some drug use do not meet indications, hard to use; Some duplication of large-scale use of the so-called drug Baogan; Some mistakenly believe that no toxic side effects of traditional Chinese medicine, indiscriminate use of non-selective. Liver in these messy and complicated drug formed under the influence of chemical reactions, inflammation and poisoning is becoming more and more weight, liver function damage growing heavier. In addition, there are other diseases caused, such as colds, diarrhea, cholecystitis, bleeding can also lead to fluctuations in liver function. The above reasons, hepatitis B patients have to pay attention to prevention.

A healthy liver of a healthy lifestyle is essential for every minute exercised liver are more than 5000 important function, in order to maintain the normal operation of your body. If you have the following risk factors, you will likely suffer from liver disease In your work, you come into contact with blood or body fluids. You often exposed to poisons or chemicals, such as spray cleaners, pesticides, paint, under, or long-term smoking environment. You often injecting drugs, especially with people sharing needles. You with more frequent sex partners, unprotected sex life. Have you ever used non-sterile needles for tattoos or puncture. You alcoholism. Even if it is not a lot of alcohol also have toxic side effects, especially when you drink alcohol while taking acetaminophen containing the. You regularly take some herbs or herbal preparations, too large amount of vitamins may also result in liver damage. Do you have the following situations: obesity, diabetes or high triglycerides. You have received blood transfusion, then you may be suffering from hepatitis C. You are a war veterans, especially on the battlefield contact with other people's blood. If you are an answer to any of the above is yes, then you should consult your doctor and request a check of enzymes. The examination is painless, and you will delay is very dangerous.

American scholar, a study showed that normal weight older men and women, if there is a lot of abdominal fat and muscle between the fat and still have taken place the risk of type 2 diabetes. The study results were published in Diabetes Care (2003,26 372 on). Principal Investigator, University of Pittsburgh Department of Endocrinology and Metabolism, Dr. Goodpaster said that their study found that, even if it is not overweight elderly may also be suffering from diabetes, important factor is excessive body fat stored in the where. Although type 2 diabetes prevalence rate of people over the age of 65 is high, but this group of people is only 14 percent obesity rate. In contrast, the 50-year-old age group was 24%. Goodpaster believes that the elderly in obesity, insulin resistance and type 2 diabetes may be a link between. The study included in 2964 the elderly, the average age of 73.6 years, of which 48.5 percent were male and 58.3 percent for whites. 51 percent were in people with normal glucose tolerance, 21 percent of people with impaired glucose tolerance, 24% of the people suffering from type 2 diabetes. Using CT scans to determine the abdomen and thigh fat. The prevalence rate of diabetes, obesity group was higher than overweight and normal weight. 30% of obese men and 34 percent of obese women suffering from type 2 diabetes. The results showed that, despite the large amount of leg fat is similar to patients with type 2 diabetes and impaired glucose tolerance inter-muscular fat was higher than normal glucose tolerance; At the same time, the proportion of visceral fat was also higher than normal glucose tolerance. The study also found that patients with type 2 diabetes, 22% of normal weight men, 12% of women of normal body weight; the other 14 percent of men and 22 percent of women have impaired glucose tolerance. Combined with another prospective study, which means that there are 2 / 3 type 2 diabetes are not obese men, women are also similar. Goodpaster said that this prompted the elderly suffering from diabetes or impaired glucose tolerance, obesity is not a necessary condition for the distribution of fat is to determine the state of insulin resistance and glucose in the environment an important factor for stability.

For women who are full of confidence so that they doubled the chest. However, according to U.S. media recently reported that the Canadian scientists found that the chest is too large for women suffering from type 2 diabetes at greater risk. Toronto, Canada, researchers at the University of nearly 92,000 average age was 38-year-old middle-aged women were investigated. They first started to volunteer at the chest size of 20-year-old case has done a survey, then one of its young patients with diabetes chest size of a comparative study. The results showed that those who wore A cup bras women the lowest risk of diabetes; with them, compared to wear B or C cup bra cup women with diabetes should be higher than 32 percent probability; wearing D Cup odds or even sick women will be higher than 50%. The researchers analyzed the chest too much adipose tissue, may affect the cells to insulin resistance. While the incidence of type 2 diabetes and human cells to reduce the insulin sensitivity. The researchers said that the chest is one of female sexuality, its size on behalf of the state of physical development. Fengman chest looks more beautiful, but too much may be detrimental to health. In addition, type 2 diabetes is a disease in a variety of factors, through the formation of multi-year process, chest size does not play a decisive role.

According to "July 21 Lianhe Zaobao reported that the United States, new medical studies have shown that babies in the womb by the mother if the diabetes and obesity genes, a new life in the adolescent suffering from Type II diabetes risk will increase. The United States, the University of Colorado professor Tatsu Billy research team headed by the "Diabetes Care," the publication said that the impact of diabetes in the mother of the baby by a young man appeared II diabetes increased by 7 times the odds, if it is affected by the obesity, the probability will increased by 3 times. The study is 79 in the prior 20-year-old was diagnosed with Type II diabetes in young people, as well as 190 non-diabetic adolescents. Professor Billy Tatsu is estimated that 47% of young people suddenly appeared Type II diabetes is because before birth has been in its mother's body by diabetes and obesity genes. The study also found that during pregnancy the mother of pre-diabetes, diabetes than those who appear before pregnancy, their children suffer from diabetes in the future will be higher than the probability of two and a half times. Research team from the baby's height and weight index (BMI) change was found that maternal obesity so that the baby appeared in childhood overweight, resulting in increased risk of diabetes. Study concluded that, in order to avoid the sudden appearance of the young Type II diabetes, "We have to take life-long therapy, in addition to the prevention of child obesity in childhood too, but also should be reduced by women during pregnancy diabetes and obesity problems. "

Before 1980, China's diabetes incidence rate is only 0.3 percent, but now a conservative estimate of up to 3-4%, in the past have always thought that was mainly caused by genetic factors, and in recent years, the incidence has increased more than tenfold, apparently using genetic theory can not fully explain, therefore, put forward in recent years the international community receptor theory, that insulin production and play a role is to ensure that the prerequisite for the normal blood sugar, the majority of patients with type 2 diabetes produce insulin that is to say there is no problem with islet function is not bad mainly can not give full play to the role of insulin caused by elevated blood sugar. In our country, especially with the people's living standards, long-term irregular unreasonable diet, coupled with the reduction of physical activity, resulting in insulin long-term, intensive work instate, a long time, the body appeared 3 insulin resistance, blood glucose is then increased. So many patients in clinic, said: Everyone says the disease genetic,never get the disease, I would do yesterday? Is this truth. That is, the disease in addition to genetic factors, the more fat as a result of drinking too Gan, activities to reduce the lead to the rich man's disease.

Pay attention to safety First of all, the treatment of hepatitis B drug would like to emphasize safety, easy changes in hepatitis B patients treated long, single-drug treatment difficult to achieve the purpose, it is the use of combination therapy, medication safety is the primary. Years ago have used a variety of hepatitis drug, was later proved to be unsafe, for example, Vidarabine, phosphine formic acid, are likely to cause renal dysfunction. At present, the use of interferon, lamivudine and other equally serious hidden safety problems, if improperly used, choice of inappropriate or stop may lead to aggravate their condition. Chinese medicine also the existence of insecurity. Some Chinese herbs and Chinese medicine formulations have been proven to clear the role of liver damage, such as Chinese herbs Fructus Xanthii, crassirhizoma, Tripterygium, Trichosanthin, nutmeg, mint,etc.; proprietary Chinese medicines are Xiaochaihu soup, Qingdai compound pill , elimination of nuclear films,grams of silver. Therefore, in order to avoid abuse and extended, over-use, for civil prescription, prescriptions must be used with caution to prevent poisoning. There is the history of drug allergy or an allergy patients, in the event of drug-induced liver injury, we must terminate the drug use and timely to the regular hospital treatment. The pursuit of effectiveness Hepatitis B is now a lot of old drugs, such as oral famciclovir, acyclovir have been confirmed to be invalid, is now phasing out. At present, the main treatment of hepatitis B drug - anti-HBV drugs, recognized only interferon, lamivudine and other several other advertised with the nature of anti-HBV drugs, has yet to be approved unanimously. In addition, hundreds of so-called "Baogan drugs", there is only one part to improve the liver function, reducing the role of liver inflammation. Therefore, patients with medication must be taken seriously and choice should not be reckless haste, must not rely on advertising and other publicity. To promote economy Treatment of hepatitis B costly, expensive drugs are well known, the vagaries of hepatitis B patients, medication continuously, and many patients. Therefore patients with hepatitis B drug use must be prudent and less money to spend wronged. For example, with liver function JiangMei many drugs, select agents, we must take into account the economic capacity, shop around, choose low-cost drugs, such as Ganlixin injection. Many long-term efficacy of new drugs have not been determined, together with the prices are very high, should not be recommended as first-line drugs trial. For example, adefovir, State Food and Drug Administration has not yet formally approved the listing of the drug imports, and many patients have heard that the drug efficacy, and can replace lamivudine, then lost its patience, seek to fight drugs everywhere. Some also purchase of medicines from overseas on their own trial and costly, but the lack of guidance note for the use of drugs, dosage, treatment and so all I do not know, medication is difficult to predict late adverse reactions. Grasp the appropriateness The appropriateness of the principle of rational drug use is mainly reflected in the following areas: appropriate drugs according to the body in patients with diseases and conditions, a variety of factors to weigh the pros and cons of drugs to choose the most appropriate drugs. For example, early in patients with liver cirrhosis, choose anti-virus and anti-hepatic fibrosis drugs at the same time, the best effect. Appropriate dose interferon treatment of hepatitis B is very common, very meticulous grasp dose. If the dose is too small, it will not be effective; if too much dose, drug toxicity have been strong, and in patients with unbearable body. Chinese people generally believed that the appropriate dose of five million to 600 million units / day, 1 time use. An appropriate time such as long-acting interferon week 1 times a week to ensure that patients with the blood drug concentration remained in the effective range of patients can reduce the pain and trouble. Appropriate route of administration must be integrated into the purpose of drug use, drug nature, a patient's body as well as the security situation in the economy, easy and so on. Oral administration of both convenience and economy, but also less affected by the suffering of patients, on the contrary do not advocate intravenous drip easily adopted. Appropriate treatment of hepatitis B patients to emphasize the individual, the person, the principle of treatment, such as interferon treatment object, the disease must be increased in transaminase, hepatitis B virus replication in patients with positive indicators; severe or heavy unfit for use in patients with hepatitis B interferon therapy. Appropriate course of treatment in accordance with the principles of therapeutics to provide drug treatment cycle. Anti-HBV treatment and the treatment of hepatic fibrosis are persistent need of long-term effects obviously can not stop, if necessary, to extend the treatment in order to secure a stable long-lasting effect. For example, lamivudine and interferon treatment of hepatitis B, treatment need more than 1 year. However, some drugs are not suitable for long-term use, it is necessary to avoid the extension of delivery time, reduce the accumulation of poisoning, HIV drug resistance, drug-dependent, such as the emergence of adverse reactions. For example, patients with hepatitis B as soon as fever, anti-inflammatory drug use must take principle, so disease medicine only.

Ningbo University School of Medicine Affiliated Hospital of Professor liver disease, liver disease Zhejiang Medical Association vice-chairman of the credits will be Dejan Wang With the domestic and foreign research prevention and treatment of hepatitis B and the continuous progress, there is growing awareness of the chronic hepatitis B is a potentially progressive liver disease, if it is not timely and reasonable treatment, some patients will develop liver cirrhosis, And even liver cancer. Among them, particularly in recent years realize that hepatitis B virus replication and extent of the disease situation and progress is the most important independent risk factors. In other words, after a blood test, all a direct reflection of the hepatitis B virus replication of HBV DNA, the higher the concentration, for the development of cirrhosis, liver cancer, the higher the ratio. Therefore, the hepatitis B prevention and treatment guidelines at home and abroad have made it clear that in the comprehensive treatment of chronic hepatitis B, antiviral treatment is the key. China's "Guide" stressed that "as long as there are indications and conditions allow, they should regulate the anti-viral treatment." "Guide" under the impetus of China's treatment of chronic hepatitis B virus into the beginning of a new era of governance, and so have tens of thousands of patients with chronic hepatitis B benefit. However, a variety of reasons, anti-viral treatment in general is not enough standardization, and no more optimized, so that the anti-viral treatment reduced the effect of this is we must attach great importance. In view of the current problems at home and abroad in recent years, sum up new experience, as well as our clinical practice experience in this special on how to optimize the treatment of chronic hepatitis B to emphasize the following points: First, select a patient, have a good grasp of treatment, "the starting point." . Not all chronic hepatitis B patients need anti-retroviral therapy, not all are suitable for patients with chronic hepatitis B antiviral treatment, it is very important. At present, some medical units, and some expansion of the treatment of any medical personnel, would be the normal liver function has been done and liver histology of chronic hepatitis B virus carriers for the blind anti-viral treatment, the results are often difficult to be effective; more Of hepatitis B virus replication marker negative or low concentrations of non-active carriers of hepatitis B surface antigen also completely unnecessary anti-viral treatment, so that they waste a lot of money, and increase the suffering and psychological burden. This is the case, we are experts in out-patient consultations and in common. As a rule by the medical staff, eager to face the medical treatment of patients (actually a lot of patients but not carriers of hepatitis B), if even the most basic need of treatment or the suitability of treatment Dunong not clear, how can you prescribe some medicine? Knowing that if no rule or rule is not suitable to make money but to deliberately carried out the treatment should not be ruled null and void, is the essence of the hepatitis B as a money tree, is even more loss of medical ethics, it is inevitable that doctors said was a "black doctor" . As we all know, need long-term anti-viral treatment, not low cost, for most patients is a heavier burden. As a result, doctors and patients should be in accordance with China's "Guide" provides carefully selected targets of treatment. At present, domestic and international consensus, and recognized China's "Guide" provides a clear indication of the anti-viral treatment, mainly 2: HBV DNA 105 copies / ml (HBeAg negative for the 104 copies / ml); Second, alanine transferase (ALT) or 2 times the normal liver histology significant inflammatory necrosis. 2 master this indication, that is, select the most suitable for the needs of governance and rule of the object, which is to optimize the treatment of hepatitis B is a basic principle. Second, choose the right drug, the implementation of standardized and individualized treatment. On the market today was that anti-HBV drugs more and more, in particular a large number of false advertising and false propaganda, making a lot of doctors and many patients tell who is an effective drug, which is invalid or uncertain Drugs, which are made with no emphasis on fitness. We have seen many patients completely void of useful drugs and even some of the Liver is a very common Chinese medicines, have been disguising themselves as the anti-viral effects, and strange to the patients or carriers to sell high-priced so-called anti - HIV treatment. Of course, the treatment is ineffective, and spent a large sum of money wronged. Some are also strongly recommended some of the therapy is not yet mature, including some of the ongoing clinical trials, such as the treatment of hepatitis B vaccine, according to the provisions can not be any expansion of the scope of the trial, the charges should not be, but through some The legitimate supply channels so that the patient is assumed to be the pilot, assumed the cost. It is this irresponsible attitude. So who has the responsibility of doctors and patients have a rational, and should be fully aware of the current domestic and foreign anti-hepatitis B drug effective progress in the correct information, the most reliable information comes from domestic and foreign authoritative academic organizations issued guidelines for prevention and treatment of hepatitis B or Related guidance documents, most of them of a medical study, the most fully convincing scientific evidence that the evidence of evidence-based medicine, many focused on the mainstream of the collective wisdom of experts. Therefore, is to guide our direct patient services for clinicians continuously update their knowledge of the best teaching materials. At present, most of the information in a number of regular anti-liver to return to the search site, such as "net win over B" (hbver.com) is a very authoritative public can be fully trusted site. At present, at home and abroad were authentic and authoritative academic mainstream and recognized experts unanimously recommended, after the State Drug Administration formally approved the anti-HBV drug treatment, only six categories, and this is the common drugs interferon and interferon long Effect of interferon (pegylated interferon) (PEGASYS, to carry music), the nucleoside analogue drug lamivudine (Lamivudine), adefovir dipivoxil (Howe, who was in lieu of D ), Entecavir (Bo-channel) and telbivudine (than-V). These two types of drugs in six different characteristics, such as the type of interferon, on the whole course of treatment is the relative merits of fixed (generally from 6 months to 1 year), HBeAg seroconversion rate (that is, HBeAg negative, anti-HBe positive change) higher , The effect is relatively durable, less resistance variation; shortcomings of the need for injection is administered, side effects (such as fever, transient drop in white blood caused by bone marrow suppression, etc.), not suitable for those who decompensated liver function. However, long-acting interferon is superior to the general effect of interferon, a weekly injection to 1 (interferon to be an ordinary day, 1 pin). Nucleoside (acid) analogues of the common advantage of oral administration of (an ordinary day, very convenient), inhibited the virus stronger, and slightly fewer side effects and can be used to decompensated liver function; shortcomings course of treatment is relatively National (generally more than 2 years), HBeAg negative serum low, the effect of not lasting long-term application of resistance variation, the drug that may arise after the condition deteriorated. One of the first application of lamivudine, the most abundant experience, have been included in the Medicare drug use, but the rate of resistance variation out on top of the list. Adefovir dipivoxil for those who have lamivudine-resistant effects, but untreated cases of slow onset, not resistance, suitable for long-term treatment. Of which 000 are domestic, on behalf of small low-price, more suitable for low-income patients in the long-term treatment. Telbivudine is listed on the new drug, anti-viral effect is better than lamivudine, lower than the rate of lamivudine-resistant variant, also may have a higher rate of HBeAg seroconversion, but the price is also higher than lamivudine . Entecavir is a nucleoside analogue in the existing curb the virus and strong, while the lowest rates of drug resistance mutation (4 newly diagnosed cases in less than 1. /.) Drugs, but also the most expensive prices, economic conditions are more suitable for long-term Treatment. In short, these two types of medicine are six first-line treatment drug, as long as we fully understand its advantages, disadvantages, in view of the patient's condition (viral load, the level of aminotransferase), conditions (economic, health insurance) and the wishes of the individual, in full and Communication between patients and reasonable under the circumstances in which application of any of the drugs should belong to the right choice. Third, the turning point of good, timely adjustment of treatment strategies. Now the medical profession has proposed a "road map hepatitis B treatment," the concept is meant to give patients anti-retroviral therapy six months (24 weeks), the virus DNA as a decision-making level, to predict the treatment of one year and two years. If the treatment six months when the lower the viral load, and a year for two years when the better effect, the emergence of drug resistance are less likely; six months if the therapy when viral load can not be reduced to a low level, said the existing treatment Program is not satisfactory, you can consider adjusting the treatment strategy. As a result, the beginning of the treatment regardless of which type of program, once implemented should pay attention to be monitored in a timely manner, particularly HBVDNA decline in the speed and range, the faster the rate of decline, the greater the range, the effect of inhibiting the virus, the better, opportunities for drug resistance mutation Will be less. Rule by doctors and patients should attach importance to the outcome of the policy-making decisions, often referred to as the "turning point." Which will enable us to more hearts of the bottom of the treatment. The treatment of hepatitis B road map Fourth, guard against resistance, early detection, early to deal with. Nucleoside analogue to receive long-term treatment of patients with resistant virus have occurred in the possibility of mutation, and with the administration time and increase the ratio. However, different drug resistance mutation probability and a greater time difference, for example, patients treated with lamivudine-resistant mutation occurred in a higher rate, the time may be earlier. In particular the treatment of patients with slow decline HBVDNA often have a higher incidence of early-resistant variant, should be closely observed. HBVDNA through regular review and early detection of the virus rebound, that is, the drop in viral load after recovery is the occurrence of signs of resistance mutations. At this point should be conditional on the virus-resistant variation of the relevant detection and timely treatment to continue to adjust and take control of virus resistance to deal with the corresponding. Of lamivudine resistance can be used to increase the preferred long-term adefovir treatment or combination therapy with adefovir effect after a single treatment to continue; also would be able to entecavir treatment, but need to increase the dosage to 1mg (2 Tablets) / day, but there have been in patients with lamivudine-resistant strains, the occurrence of entecavir a marked increase in the incidence of drug resistance. Adefovir resistance on, plus lamivudine or to switch to entecavir. Of entecavir resistance can be used to increase or switch to adefovir. Of telbivudine resistance can be added adefovir or switch to entecavir. In short, with the increasing Nucleotides drugs, the use of these drugs increase the number of patients, prevention of drug resistance mutations, in particular, early detection, early processing of vital importance. Based on our clinical practice experience in long-term treatment-resistant variation is inevitable, but unlike in the past have been terrible NA me, as long as close monitoring and the right time, and more able to achieve the desired effect. It is always worried about is that a small number of patients, in order to save time and money that he pharmacies to the purchase of medicines, or even six months, more than one year are not reviewed until the deteriorating condition was eager to visit, only one review found that the virus not only indicators rebound Pick-up, liver function and increase the rebound, then re-adjust the treatment more difficult, and certainly an increase of fees. These lessons must be learned. Fifth, adhere to treatment, with full course of treatment, to grasp "the ultimate goal." Research and clinical practice shows that the anti-viral chronic hepatitis B treatment, as in the treatment of high blood pressure, diabetes, the need for long-term treatment in order to maximize the sustained suppression of hepatitis B virus replication in order to achieve progress in disease control, prevention of the occurrence of liver cirrhosis and liver cancer goal . So for every anti-virus treatment of patients, all intended to make long-term treatment, interferon treatment for at least 6 months, it normally takes a year; the treatment of nucleoside drugs, at least 2 years, especially in HBeAg-negative Most want a more long-term treatment. Any treatment must not be interrupted, even go out to meet with the tourism also full of drugs, medication on time. Lv Jian some of our patients, for various reasons, the half-way unauthorized drugs alone, inadequate treatment or early termination of treatment, resulting in relapse and even their problems. For the treatment of "the end", there had been consensus at home and abroad, is to meet the basic requirements of HBV DNA disappeared, normalization of liver function after treatment of the consolidation of more than 1 year, preferably at the same time achieve HBsAg negative, the effect may be more lasting.

With the anti-hepatitis B virus in recent years, the constant introduction of new drugs listed, chronic hepatitis B (CHB) treatment effect than 3 years ago has been greatly improved. From 2005 listed one after another in our country Dipivoxil of nucleoside analogues, entecavir, as well as the newly listed this year, telbivudine and lamivudine in the initial together to build a nucleoside analogue treatment of hepatitis B Strong Powerful ammunition depots. In addition, apart from the nucleoside analogues, and those with chronic hepatitis B treatment of the antiviral drug interferon in recent years has also launched a long-acting form of polyethylene glycol, as compared with ordinary further enhance the efficacy of interferon. A few days ago, to be held in South Korea's Cheju Island in emerging markets strategy seminar on the treatment of chronic hepatitis B, liver disease experts in international Auckland, New Zealand, Professor Edward Gane of the proposed treatment of chronic hepatitis B individual optimization of the new strategy, that is, the combination of chronic hepatitis B treatment Road map, on a regular basis to assess the effect of the adjustment of drug treatment programs so as to enhance the treatment of chronic hepatitis B, reducing or even prevent the disease in patients with liver cirrhosis, liver cancer, and other long-term complications. Previously held in Kyoto, Japan in the Asia-Pacific Association for Study of Liver Diseases (APASL) 17th Annual Meeting, attended by international experts in liver disease combined with the treatment of chronic hepatitis B road map, as well as the United States in February by the association for the study of liver disease (AASLD) announced The latest edition of "Guide to hepatitis B prevention and treatment" had a thorough exchange of views. They reached the wishes of one of the principal is: the initial treatment for patients from the very beginning treatment should be preferred anti-virus capability, the low rate of drug resistance. In the recent publication of academic activities, a growing number of studies have shown that the treatment of chronic hepatitis B for example, when a poor effect of drugs (such as six months into the treatment can not effectively minimize the level of hepatitis B virus ), The switch to more antiviral drugs in another, to more effectively suppress the virus, such as the level of the virus less than Inhibition to detect. If the initial treatment and appropriate use of potent anti-viral drugs, to minimize the level is an effective way to promote the resumption of regular transaminase and serum HBeAg conversion, to reduce the incidence of resistance in order to achieve sustained effect. Experts said that the existing 4 nucleoside analogues and interferon agents for the treatment of chronic hepatitis B to address a variety of difficulties, such as poor efficacy, HBeAg negative rate on the low side, the emergence of drug resistance, as well as Security concerns, and so on, provides a wide range of application portfolio means. Doctors can change in patients with specific conditions, the use of individualized treatment. For example, patients with a higher baseline level of hepatitis B virus, hepatitis B virus in the body that is to copy a large number of the option potent anti-viral drugs, such as telbivudine, entecavir; patients, "Dasan Yang", faced with further education, employment, etc. , Will need to HBeAg negative, "Xiao Sanyang," could be considered a higher rate of negative interferon or telbivudine; taking into account the long-term anti-viral treatment of security, not only to consider the option of using a longer time, Application of experience or more nucleoside analogues lamivudine in the United States was the only FDA pregnancy that the B-class telbivudine, or choose a low incidence of drug resistance and side effects of the low incidence of entecavir. Turning to interferon treatment, Gane, a professor pointed out that the treatment of patients with a baseline of a number of conditions, such as age, sex, level of aminotransferase, the level of hepatitis B virus, and so on, the effect of interferon can have a significant effect, this view has been Wide range of academic accreditation. The application of nucleoside analogues in the treatment of chronic hepatitis B clinical study results showed that telbivudine treatment, "Dasan Yang," The patients in the treatment of baseline level of aminotransferase is greater than twice the normal patients, a better effect; drug Six months can reach 49% of patients with hepatitis B virus detection level of less than; treatment for two years, 86% of patients with hepatitis B virus levels remain negative, 49% of patients achieved a "Dasan Yang" to the "Three Yang ", 85% of the patients with normal transaminase. Based on a number of recent studies, as well as relevant guidelines of the view that for the hepatitis B virus genotype A and Type D patients, interferon is superior to the effect on B-and C-type patients; patients with genotype of nucleoside Analogues did not affect the basic effect. In addition, although chronic hepatitis B require long-term anti-viral treatment, but "Dasan Yang" and the treatment of patients, "Xiao Sanyang," and patients are different, so if you need long-term treatment, the drug's long-term security must be considered as a One of the important factors; the treatment of choice in the process of potent drugs can quickly detect the virus less than Inhibition, and the high rate of the e antigen negative / conversion rate is the attending doctor must first focus of attention.

Source: Sohu health Zhuang Hui Academy of Sciences: the basis of Peking University School of Medicine professor of biological pathogens, and doctoral tutor, the Chinese Academy of Engineering. Zhuang Hui Sohu Health Channel recently invited on the basis of Beijing University School of Medicine professor of biological pathogens, the Chinese Academy of Engineering and Professor Zhuang Hui users on the treatment of hepatitis B-related issues. Moderator: You mean the virus is not down the level of treatment of hepatitis B is one of the main signs? Zhuang Hui Academy of Sciences: Yes. The first, we asked the general what is, first, down to the level of the virus. Second, the resumption of normal transaminase, the drug is not a normal down, because the virus is a small, drop transaminases, both linked. Light drop transaminases, the virus did not do it. Third, Dasan Yang is the original e antigen-positive to become the e antigen negative. And e-positive, this is the third. Moderator: This refers to the so-called Da Sanyang it? Zhuang Hui Academy of Sciences: Dasan Yang. Xiao Sanyang there will be no conversion of the problem. Meet three criteria, can not stop immediately, but also to continue treatment, six months after a search but also, if unchanged, could stop. Six months later another two or three times a check or change, you can stop. Moderator: How many patients can be treated to meet you just said these standards. Zhuang Hui Academy of Sciences: 20 to 30 per cent of patients. Zhuang Hui Academy of Sciences: But according to the treatment of patients with time, the patient's condition. Xia Bulai also some five years, six years have had to eat, everyone's situation is different, generally average about 30%. But one might get the drug.

The vast majority of patients with resistance to its own circumstances, such as Mangranbuzhi not adjust treatment will eventually lead to worse Chinese hepatitis B is a big country, a total of 120,000,000 people living with hepatitis B, in which Guangdong is the "hardest hit." According to the latest version of the "guidelines for prevention and treatment of hepatitis B", in order to achieve the goal of the treatment of hepatitis B, hepatitis B patients must adhere to the long-term anti-viral treatment. However, the Guangdong Provincial Institute of Infectious Diseases director, hospital infection in the South of internal medicine Professor Hou Jinlin pointed out that the anti-viral treatment, although the effect was recognized by the medical profession, but after taking the virus mutation and drug resistance has become a clinical problem can not be avoided. According to estimates, since the anti-viral drugs in China has been used in clinical, it is estimated that 100 million patients have used or are in use antiviral treatment, which has an estimated 100,000 drug resistance of hepatitis B patients, and The vast majority of their situation Mangranbuzhi ultimately delaying treatment led to the deterioration of the condition. Antiviral drugs Yizhi virus mutation Hou Jinlin, recognized at home and abroad and effective anti-viral drugs, including the main types of interferon and nucleoside (acid) analogue two broad categories. Oral nucleoside (acid) analogues can inhibit virus replication, in the short term can play a significant effect, but its drawback is the need to maintain long-term treatment, such as "Da Sanyang" Patients want to eat at least two years or more, "Xiaosan Yang" is a longer course of treatment of patients, continue to have poor efficacy of drugs. In addition, the use of nucleoside antiviral drug therapy is likely to occur, the disease is easy to stop after a rebound. It is learned that in clinical practice the most widely used nucleoside analogues lamivudine is, statistics show that patients taking the drug a year after the virus mutation rate of 14%, 38% for the second year, third year 49% , The fourth year of up to 66%. The new out of adefovir dipivoxil treatment before the 3-year low although the rate of drug resistance, "Xiao Sanyang" to the treatment of patients with Article 5, the virus mutation rate may reach 29%. In addition, was recently approved for clinical telbivudine, although more than lamivudine suppression of the virus and improve the ability of e antigen seroconversion dual role, but after the second year in the use of virus mutation rate is not Low. It is due to the existence of these problems in the long course of treatment, patients and doctors must have felt at the end, attach great importance to the resistance, the use of antiviral drugs to a patient's full understanding of this important information. B preferred to deal with anti-retroviral therapy In order to prevent hepatitis B virus outbreak in the human body, is the most effective way to carry out anti-viral treatment. In the just-concluded Asia-Pacific Association for Study of Liver Diseases 17th Annual Conference of the thousands of international disease experts called on the United States the use of association for the study of liver disease in 2007 released the latest version of "hepatitis B prevention and treatment guidelines." The guide is of the view that patients with hepatitis B should adhere to long-term anti-viral treatment. Although anti-retroviral therapy has been recognized by the medical profession, however, pointed out that Hou Jinlin, early single type of anti-viral drugs, in the event of resistance and response to virus mutation, it can not substitute for the use of drugs in the treatment of hepatitis B This is the most prominent issues . Worst of all, not only this Mangranbuzhi patients, many doctors are not aware of the problem. According to estimates, China is at least 100,000 of the emergence of drug resistance in patients. Despite the anti-viral drugs continues to introduce new patients with drug resistance, the use of alternative drugs or more of the drug has become a reality, the need to attach great importance to the specialist, do not miss the treatment of patients with the "turning point" and lead to further deterioration. In the treatment of drug resistance can be prevented Although the issue of hepatitis B in clinical resistance to the doctor brought a lot of problems, but fortunately, the types of antiviral drugs is increasing. It is reported that as early as the only antiviral drug lamivudine, but now the "family of antiviral drugs" has been "growing", 6 kinds of drugs have been approved by China for the treatment of anti-hepatitis B virus. According to the present level of anti-viral treatment, if patients with drug resistance, fully replacing the drug or drugs, the treatment of joint. Hou Jinlin said that the choice of future anti-viral treatment for hepatitis B, the drug may have some mixed use, could play a "cocktail" therapy, can effectively reduce the resistance, but also enhance the effect. Optimization of treatment can not keep up The number of antiviral drugs, this is a good thing, but now there is an additional problem: In the past few drugs, compared with single treatment, the drug is more, treatment should relevant diversification, as a result of both diagnosis and treatment of people, As a result of diagnosis and treatment when they should be. What is the time to start anti-retroviral therapy? How to determine whether the emergence of drug resistance in patients with HIV and mutation? Emergence of resistant virus and how to deal with variation? When treatment can come to an end? This requires a doctor to determine the appropriate and processing, which currently do not have a unified specification. Anti-retroviral therapy is the most crucial part, Hou Jinlin be summed up as a starting point to find a treatment, the inflection point and end point. Only by grasping the treatment of hepatitis B three points in order to achieve the treatment of the "four transformations" - to maximize the efficacy and minimize resistance, cost-effective and individualized treatment. The so-called "starting point", is a doctor to decide when to start anti-retroviral therapy, the treatment is not a problem, in accordance with the norms, as long as the virus and the level of aminotransferase index reached a certain target, they should start antiviral therapy. Hou Jinlin, said the most troublesome patients to determine whether there is a turning point of the treatment. What is meant by "turning point", he played a vivid metaphor: the Yangtze River in the south have been the source of torrents, if there is no "turning point" will flow to South Asia, but fortunately in the territory of Yunnan Province, the Yangtze River to the east and break, making only in the Yangtze River Now the lower reaches has become a fertile land of fish and rice. To receive anti-retroviral therapy for patients, if treated early in the resistance will be able to find the clues, and in the scramble in front of a timely replacement therapy and drug treatment programs, do not give the virus the opportunity to make a comeback, and this is the treatment of captured " Turning point. " And found that attention to the "turning point", will embark on the rehabilitation of the road condition, to the neglect of the "turning point", it is likely On the contrary, will eventually become irreparable consequences. Doctors found that "turning point", its significance as a farmer sowing seed in the spring, summer harvest will be able to forecast and decide whether to replant some crops. However, Hou Jinlin regret that, despite the "turning point" is so important, but in the actual treatment, liver disease, many non-professional doctors did not realize that this did not advise patients on a regular basis to carry out quantitative virus, drug resistance and liver function tests Lead to the treatment of patients with missed opportunities in vain. Medication can decide on the next six months treatment How to find the treatment of the "turning point"? Hou Jinlin said that the medical profession has proposed a "road map hepatitis B treatment," the concept is meant to give patients anti-retroviral therapy six months (24 weeks), the virus DNA as a decision-making level, to predict the treatment of one year and two years at the time of Effect. If the treatment six months when the lower the viral load, and a year for two years when the better effect, the emergence of drug resistance are less likely; six months if the therapy when viral load can not be reduced to a low level, said the existing treatment Program is not satisfactory, you can consider adjusting the treatment strategy. Young people preferred initial treatment immune anti-retroviral therapy For some young patients with newly diagnosed, such as children, young people in particular to prepare children, as well as the use of nucleoside (acid) analogue-resistant patients, but also considering Immune regulation of interferon-type anti-viral drug treatment. Hou Jinlin, some young patients when infected with hepatitis B virus, due to the virus in the body longer, so that the immune cells it resulted in paralysis, is the misconception that the body's normal cells, the bad guys do not take a pro-active " Brought to justice. " Immune-based anti-virus treatment is the body in the reconstruction of the internal confrontation of the hepatitis B virus defense mechanisms, first of all, "wake up" immune cells, it keep their eyes open and identify the disorder in the body for hepatitis B virus, and then further to eradicate these invasive , To protect the body's normal operation. The human immunodeficiency virus, hepatitis B and the "battle" consists of two phases: First, the eradication of the virus in the blood, in order to clear the period of serum; Second, the eradication of the Organization of the virus, the hepatitis B virus replication Zhi Dao "Lao Chao", which is Removal of immunity period. Young people are in the immune clearance phase, based on the use of immune clearance of interferon-type anti-viral treatment than other age groups of patients better. Need to be reminded that the use of some types of interferon patients did not take an early response to emerging or effect on the drug on its own. Hou Jinlin reminded that this was not recommended for the treatment of some types of interferon response of patients a few months after the emergence of e antigen negative, followed by the withdrawal of about 10% of patients follow-up effects, not only will affect the free drug efficacy Will ultimately affect their treatment process.

Experts warn: Do not easily be cured of hepatitis B, not to cure hepatitis B credulity Recently, a "country of the first hepatitis B patients with hepatitis B removed the hat," the reports have aroused considerable public concern. Reported that the adoption of long-acting interferon antiviral treatment, has 103 domestic patients with chronic hepatitis B surface antigen conversion, remove the hepatitis B "hat." A report published by the media, immediately aroused the concern of many experts, hepatitis B and patients with questions. To that end, reporters around the treatment of hepatitis B-related issues in an interview with the China Institute of Integrated Traditional and Western Medicine liver disease professional members of the Commission, the People's Liberation Army 302 Hospital of Integrated Traditional and Western Medicine director of liver disease, the chief physician Dr. Liu Shijing. Dr. Liu said that the clinical cure 103 people devoid of any meaning, clinical cure and complete cure hepatitis B is different from the two concepts; In addition, immune reconstitution is a complicated systematic project, rely on one or two drugs be difficult to achieve. As we all know, the treatment of chronic hepatitis B drug effects have not yet, but the hepatitis B disease can be controlled. The hepatitis B treatment is bound to be a long-drawn-out battle of Marathon. ≠ completely cured of hepatitis B clinical cure Liu Jing of the view that the abnormal liver function, hepatitis B replication positive indicators, there are clinical symptoms of hepatitis B patients, more objective scientific criteria to determine the effect can be divided into two types: one is the real goal - clinical cure, and the other is Ideal goal - to clear the virus. In accordance with current medical standards, complete cure chronic hepatitis B is very difficult, only a very small number of patients through the correct treatment can achieve complete cure. According to China's "clinical diagnosis based on improved standards of cure" and treatment of hepatitis B clinical cure it easier to achieve a level, the standard is: The main symptoms disappear; hepatomegaly disappeared, no liver tenderness or pain call; liver function Back to normal. But in order to meet the standard cure is very difficult. As a result, tens of millions of patients with hepatitis B can not be cured completely cured and confused. Hepatitis B cure what is the standard? (1) completely cured. Through proper treatment, patients with liver function blood tests check series are entirely normal, hepatitis B virus HBV occurred series of indicators DNA, HBV surface antigen, e antigen negative, liver puncture organizations immunohistochemical examination of hepatitis B virus core Antigen on the surface antigen disappear, so that the results of more than two years to keep time. (2) the basic cure. Through proper treatment, patients with liver function blood tests check series are entirely normal, hepatitis B virus HBV occurred series of indicators DNA, e antigen negative and e antigen and the emergence of e-Serological conversion (B "Da Sanyang "To" Xiao Sanyang "), liver puncture organizations immunohistochemical examination of hepatitis B virus core antigen disappear, so that the results of more than two years to keep time. Dr. Liu pointed out that at present there are 8 percent below a thorough patients can be cured, there are about 30% of patients can be cured basic. This is part of the viral replication in patients with negative indicators, normal liver function and liver tissue virus core antigen also disappeared, inflammation of the liver biopsy or minor static, almost no infectious, disease basic block, the occurrence of liver cirrhosis or liver cancer Significantly reduced the probability; more than 70% of patients can be active in the right treatment, the slow pace of progress in the disease, access to clinical improvement. How do we get the standard cure? Grasp the timing of the treatment. When patients with hepatitis B screening tests appear alanine transferase increased, it is best for the normal limit of 2 times, 10 times, indicators of hepatitis B virus replication (HBV DNA, HBV e antigen) positive, Liver function in compensatory stage, this time for the treatment of hepatitis B in the best time; correct and reasonable use of drugs; patients must be treated seriously the implementation of the program should not stop without authorization or termination of treatment, the drug can not be replaced frequently. So that there is no HBsAg negative ideal drug Dr. Liu believes that the treatment of hepatitis B virus is the core of the treatment of hepatitis B, from 1992 to 2005, there are 5 kinds of antiviral drugs in the international community have been approved for the treatment of HBV. 5 this drug are: general interferon α-2b, lamivudine, pegylated interferon α-2a, entecavir and adefovir. One common use of interferon α-2b longest, more than 10 years, 7 years has been the use of lamivudine, pegylated interferon α-2a and two years after the use of adefovir, entecavir less than A year. At present, entecavir and adefovir, and other new nucleoside analogues are increasingly used for clinical, as the two long-term drug use, the less likely the virus mutate more lasting effect. Entecavir suppression of hepatitis B virus, the fastest, early response rate as high as 90% of patients receiving treatment in the majority of hepatitis B virus DNA was negative, the use of the drug within two years, no variation of the virus, the use of 3 years, about 2% Variability in patients with the virus. From the suppression of the virus, the speed and effectiveness, entecavir most effective. However, entecavir listed on the official use of a relatively short time, is currently hard to confirm the drug's long-term effects. Adefovir relatively low price, but less than the effectiveness of anti-viral drug entecavir, the initial use of anti-viral drug treatment option for patients, about 60% in the treatment of six months to a year after the emergence of hepatitis B virus DNA can be negative, but If the drug replacement therapy with lamivudine treatment failure cases, the effect of a lot worse. In addition, large doses of the drug or with the potential to cause long-term use in patients with renal damage. Interferon alone can be difficult to achieve treatment of hepatitis B immune reconstitution Liu Jing of the view that medical scientists have long committed to the Hepatitis B immune regulation of research will have thymosin, interferon, IL, as well as the treatment of hepatitis B vaccine for hepatitis B treatment to try and break the hopes of hepatitis B immunization Tolerance, the reconstruction of hepatitis B patients immune system. But these attempts have not achieved satisfactory results. Hepatitis B infection due to the continued is still the basis of a number of issues not yet clear, for example, the genetic type of virus, the immune genetic characteristics of the virus, immune factors, cytokines, and antigen recognition, such as liver cell apoptosis. Reconstruction of the body's immune system can only be an ideal, but the distance is too early to success. In addition, the use of interferon, the body's immune cells can improve the ability to identify and enhance the ability to remove T cells, but the antiviral effect of interferon is limited to replication of hepatitis B virus DNA, and can not be present in the liver to remove the nucleus of the hepatitis B virus Copy template cccDNA, after stopping the virus can reproduce again, and has been unable to clear the host DNA integration of viral genes, it is difficult to express the disappearance of HBsAg. Despite the variety of interferon treatment of hepatitis B will play some role in immune regulation, but regulation is very limited. China promulgated the latest "Guide to prevention and treatment of chronic hepatitis B," pointed out that the regulation of immune therapy treatment of chronic hepatitis B is one of the important means, but is still a lack of specific immune hepatitis B treatment. Only through long-acting interferon treatment of hepatitis B, it is impossible to achieve reconstruction of the human immune system. Moreover, interferon treatment of hepatitis B and not everybody can use, if the improper use of the time, it will lead to the deterioration of the disease.