Knowledge of hepatitis B virus


Hepatitis B virus (HBV) is a liver tropic virus DNA in mammals section of a virus. Complete HBV particle diameter of only 42nm, also known as Dane particles. The tiny particles coated with the core into two parts. On the envelope protein is often said that the hepatitis B surface antigen (HBsAg), HBsAg itself does not infectious. Contains the core of the core antigen (HBcAg) and e antigen (HBeAg), and so on, is the main body of viral replication. HBV strong resistance, tolerance to 60 ℃ 4 hours and the general concentration of disinfectant, boil for 10 minutes, 65 ℃ 10 hours or high-pressure steam sterilization can be inactivated. 30-32 ℃ in the serum to save for 6 months, -20 ℃ in 15 years to save. Primates such as chimpanzees, and so susceptible to the HBV, and as experimental animals. HBV in vitro have not yet achieved satisfactory results. The HBV antigen-antibody system: 1. Antigens on the surface and surface antibody (anti-HBs) adults exposed to HBV after the first 1-2 weeks, 11-12 weeks at the latest blood in the first HBsAg. In patients with chronic and asymptomatic carriers in a sustainable existence for many years. Anti-HBs seen in the HBsAg negative after a period of time, the disease in the recovery phase began in 6-12 months and gradually rose to a peak, after falling gradually to negative 10 years, is a kind of protective antibodies. In addition to the foreign blood, HBsAg was also present in various body fluids and secretions such as saliva, urine, semen, is an indirect indicator of the existence of HBV. 2. Core antigen and core antibody (anti-HBc) in the serum of anti-HBc seen in the emergence of HBsAg after 3-5 weeks, when anti-HBs has not yet appeared, HBsAg have disappeared, only to the detection of anti-HBc, at this stage as the Window period (windowphase). IgM anti-HBs hepatitis B exists only in the acute stage of chronic hepatitis and acute phase, meaning the differential diagnosis. Low level of HBV infection, the serum can occur in a separate anti-HBc-positive. 3.e with e-antigen (anti-HBe) HBeAg generally only found in the serum HBsAg positive, HBV is a copy of the activities and marking communicable important. Anti-HBe exist for a long time, has prompted HBV DNA and host DNA integration.

1 comments:

Anonymous said...

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