LuckCong's Health Blog

Blumberg, a professor in the report, HBV and the subsequent discovery of HBV vaccine is derived from the original serum protein-related basic research, and in fact did not expect that R & B in the area have so much relevance. Blumberg, a professor at before, many scientists are trying to find the cause of hepatitis pathogenic micro-organisms, but the results did not. Blumberg was the main study of the serum antigen genetic polymorphism and susceptibility to disease. They used the spread of immunization techniques of blood transfusion had a large number of patients (such as hemophilia, leukemia) in the blood samples for research. In 1963 he found that living in New York, 1 case of hemophilia patients with a serum of indigenous Australia antigen in human serum react. As a result of this antigen was first found in Australia, so Blumberg called Australia antigen. Blumberg was in the crowd, many of which have been studied and found that this antigen in Asia and Africa among high positive rate, and the health of people in Europe and the United States was low, but in Europe and the United States have liver disease characterized by crowd The positive rate is higher. Blumberg also examined, such as Australia antigen with leukemia and Down's syndrome and found that children with Down's syndrome in Australia antigen positive rate higher, but if the parents of children with Australia antigen positive, but also occur in children with hepatitis without jaundice . Based on these clues, Blumberg and so on the assumption that Australia antigen and hepatitis, subsequent research has confirmed that indeed Australia is the HBV antigen, that is, HBsAg. Later, through observation and transmission electron microscopy experiments confirmed that the Australia antigen and the hepatitis viruses can cause indeed. From this point of view, HBV found the whole process is not designed in advance, but stumbled several times. Later studies found that human serum HBsAg and HBsAb at the same time there are very few, and indeed HBsAb positive effect on HBV are immune. Blumberg and Millman, a professor of specific techniques used to separate HBsAg with the virus, attenuated and inactivated for HBsAg, and this is the first vaccine production process, of course, now widely used in the vaccination of hepatitis B vaccine using recombinant methods of expression Hepatitis B surface antigen. Currently, HBV has become the world's most common source of infection, HBV-related diseases each year as a result of the death of about 60 to 1,000,000, while the mortality HBV infection (15% to 25%) than HIV infection (100% ), But because of the large number of HBV-infected people, so the total number of deaths (5570 to 92,800,000) is much higher than die from HIV-infected people (34,000,000). It is gratifying that with the hepatitis B vaccine immunization program to promote, HBV infection rate has dropped significantly. Since 1986, China began to implement infant HBV vaccine immunization program so far, those who have hepatitis B vaccination serum HBsAg positive rate in history has control of 16.3% (879/5397 patients) down to 1.43% (horizontal Research) and 1.81% (Queue Research). Vaccination among HBsAg positive rate of decline will be indirect effects of vaccination and not susceptible. Italy's studies have shown that the majority of the members of the unvaccinated group of serum HBsAg-positive rate of decline, suggesting preventive vaccination has the effect amplification. In addition, HBV vaccination can to prevent the occurrence of hepatocellular carcinoma, China Taiwan, South Korea and Canada, studies have confirmed this. Blumberg, a professor final appeal, according to the current situation, not only to continue to promote hepatitis B vaccination to prevent the occurrence of hepatitis B, but also to take effective anti-HBV treatment, if we can strongly inhibit HBV DNA level, you can Reduce infectious and ultimately the number of hepatitis B infection will be further reduced.